C57BL/10J Mouse Liver Fibroblasts

Description

C57BL/10J Mouse Liver Fibroblasts primarily originate from the hepatic interstitial tissue and belong to the non-parenchymal cell population of the liver. These cells express fibroblast-specific marker vimentin and are involved in extracellular matrix (ECM) synthesis and tissue repair. They play a role in maintaining liver homeostasis and injury repair by secreting ECM components and growth factors (e.g., TGF-β, PDGF) to regulate the hepatic microenvironment. However, under chronic liver injury (such as carbon tetrachloride-induced liver fibrosis models), their excessive activation leads to abnormal accumulation of ECM, promoting the progression of liver fibrosis and even cirrhosis. Detailed analysis of the hepatic fibroblast phenotype in C57BL/10J mice is essential for understanding activation status and functional transitions in liver disease models, particularly in the context of fibrosis progression and extracellular matrix remodeling. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.