C57BL/10J Mouse Spleen Fibroblasts

Description

C57BL/10J Mouse Spleen Fibroblasts are primary fibroblasts isolated from the spleen tissue of pathogen-free C57BL/10J mice. These cells exhibit a spindle-shaped morphology and adhere to culture surfaces, characteristic of fibroblasts. They play a crucial role in maintaining the structural integrity of spleen tissue by producing extracellular matrix components such as collagen and elastin, contributing to the C57BL/10J splenic stroma. In response to injury or inflammation, these fibroblasts become activated, proliferate, and migrate to the site of damage, contributing to tissue repair and fibrosis, and reflecting the typical functional characteristics of fibroblasts in mouse spleen models. They are commonly used in research related to fibrosis, wound healing, and tissue remodeling. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.