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Primary Cells

C57BL/6 Mouse Brain Microvascular Endothelial Cells

  • For research use only

Cat No.

ABC-TC3175
Product Type

Mouse Primary Cells
Cell Type

Endothelial
Species

C57BL/6 Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Storage

Liquid Nitrogen

C57BL/6 mouse brain endothelial cells (MBREC) are isolated from tissue of pathogen-free laboratory mice.

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  • C57BL/6 Mouse Brain Microvascular Endothelial Cells
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Brain Microvascular Endothelial Cells

Description

C57BL/6 Mouse Brain Microvascular Endothelial Cells are primary cells isolated from the brain tissue of pathogen-free laboratory mice, serving as an ideal model for C57BL/6 brain microvascular assays. Following primary culture, these cells are cryopreserved. They are dynamic gatekeepers of brain homeostasis, integrating barrier integrity, selective transport, hemodynamic regulation, and neural repair. C57BL/6 Mouse Brain Microvascular Endothelial Cells are characterized by the expression of markers including VE-cadherin (CD144) and CD31/PECAM-1. Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

C57BL/6 Mouse Brain Microvascular Endothelial Cells,Mouse Brain Microvascular Endothelial Cells,Microvascular Endothelial Cells,ECs,C57BL/6 BMVECs
Species

C57BL/6 Mouse
Cat.No

ABC-TC3175
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • C57BL/6 Mouse Brain Microvascular Endothelial Cells serve as a critical in vitro and in vivo model to study cerebrovascular pathologies, particularly focusing on blood-brain barrier (BBB) dysfunction, and age-related microvascular degeneration. For example, by analyzing molecular pathways like claudin-5 downregulation and endothelial nitric oxide synthase (eNOS) impairment in ischemic stroke or aging models, these cells could help elucidate mechanisms of BBB leakage, cerebral hypoperfusion, and neuroinflammation. Additionally, these cells can be used in assays of cell-cell adhesion, migration, vascular tube formation, or transendothelial electrical resistance (TEER).

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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