C57BL/6 Mouse Coronary Artery Endothelial Cells

Description

C57BL/6 Mouse Coronary Artery Endothelial Cells are primary cells isolated from the coronary artery of pathogen-free laboratory mice, serving as a classic model for C57BL/6 myocardial circulation research. Following primary culture, these cells are cryopreserved. These cells are capable of self-renewal and sustain vascular homeostasis through nitric oxide-mediated vasodilation, platelet aggregation regulation, and selective permeability via tight junctions. Studies confirm their implication in atherosclerotic plaque rupture, diabetes-induced endothelial dysfunction, and stent thrombosis models due to impaired reendothelialization. These cells are validated by endothelial markers VE-cadherin, von Willebrand factor (vWF), and CD31/PECAM-1. For optimal performance, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.