C57BL/6 Mouse Intestinal Cells

Description

C57BL/6 Mouse Intestinal Cells are primary cells isolated from the duodenal, jejunal, ileal, and colonic tissue of pathogen-free laboratory mice. These cells primarily reside in the epithelial lining and lamina propria of the small intestine (duodenum, jejunum, ileum) and colon. Following primary culture, these cells are cryopreserved. The cells orchestrate crypt-based epithelial regeneration, nutrient absorption, mucus barrier secretion, and immune modulation. Studies show their implication in inflammatory bowel disease (IBD) due to Gip1-mutant stem cell dysfunction, colorectal cancer, and infectious diarrhea via bacterial pathogen disruption of tight junctions and ion transport. Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.