C57BL/6 Mouse Intestinal Endothelial Cells

Description

C57BL/6 Mouse Intestinal Endothelial Cells are primary cells isolated from the intestinal tissue of pathogen-free laboratory mice, serving as a key model for investigating intestinal angiogenesis in mice and characterizing mouse intestinal blood vessels. These cells primarily reside in the microvasculature of the intestinal mucosa, specifically lining the capillary networks of intestinal villi, crypt regions, and submucosal vessels. Following primary culture, these cells are cryopreserved. The cells play critical roles in maintaining vascular integrity by regulating permeability, facilitating immune cell trafficking, and supporting angiogenesis. Studies demonstrate their implication in inflammatory bowel disease (IBD), radiation enteritis, and diabetic microangiopathy, where endothelial dysfunction contributes to disease pathology. These studies drive therapeutic development for vascular normalization. Phenotypic validation is confirmed by the endothelial markers CD31/PECAM-1 and VE-cadherin, demonstrating their vascular functionality. For optimal performance, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.