C57BL/6 Mouse Intestinal Mesenteric Endothelial Cells

Description

C57BL/6 Mouse Intestinal Mesenteric Endothelial Cells are primary cells isolated from the intestinal tissue of pathogen-free laboratory mice. These cells reside exclusively within the vascular networks of the intestinal mesentery—specifically lining arteries, veins, and capillaries traversing the mesenteric arcades that connect the intestinal wall to the abdominal cavity. Following primary culture, these cells are cryopreserved. The cells regulate vascular barrier integrity, modulate angiogenesis via VEGF signaling, and facilitate immune cell trafficking. Studies have demonstrated their involvement in inflammatory bowel disease, radiation enteritis, and mesenteric ischemia-reperfusion injury. Phenotypic validation is confirmed by the endothelial markers CD31/PECAM-1, VE-cadherin, and von Willebrand factor (vWF). For optimal performance, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.