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Primary Cells

C57BL/6 Mouse Lung Fibroblasts

  • For research use only

Cat No.

ABC-TC3212
Product Type

Mouse Primary Cells
Cell Type

Fibroblast
Species

C57BL/6 Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Storage

Liquid Nitrogen

Mouse lung fibroblasts (MLUFC) are isolated from tissue of pathogen-free laboratory mice.

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  • C57BL/6 Mouse Lung Fibroblasts
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Lung Fibroblasts

Description

C57BL/6 Mouse Lung Fibroblasts are primary cells isolated from the lung tissue of pathogen-free laboratory mice. These cells primarily reside in the peribronchial and perivascular connective tissue, alveolar interstitium, and subpleural spaces. Following primary culture, these cells are cryopreserved. The cells drive extracellular matrix remodeling (collagen/fibronectin deposition), regulate immune responses via cytokine secretion (TGF-β/IL-6), and facilitate fibrosis through myofibroblast transition. Studies have implicated them in idiopathic pulmonary fibrosis, asthma-associated airway remodeling, and chronic obstructive pulmonary disease. These mouse fibroblasts are characterized by their spindle-shaped morphology and expression of FSP1/S100A4. For optimal performance, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

C57BL/6 Mouse Lung Fibroblasts, Mouse Lung Fibroblasts, Lung Fibroblasts, Fibroblasts, FibCs, C57BL/6 Lung Fibroblasts
Species

C57BL/6 Mouse
Cat.No

ABC-TC3212
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • C57BL/6 Mouse Lung Fibroblasts can be used as an in vitro cell model to study the pathogenesis of fibrotic lung diseases in conditions such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Researchers can utilize these cells to investigate TGF-β/Smad3 signaling pathways involved in collagen overproduction and matrix stiffening characteristic of IPF, examine IL-13/STAT6 mediated pathways contributing to airway remodeling in COPD, and study progressive alveolar destruction processes in chronic lung diseases. This system helps elucidate extracellular matrix accumulation, alveolar stiffness, and airway remodeling.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are C57BL/6 Mouse Lung Fibroblasts?

    C57BL/6 Mouse Lung Fibroblasts are specialized fibroblast cells derived from the lung tissue of C57BL/6 mice. They play a key role in maintaining the structural integrity of lung tissue by producing extracellular matrix proteins and supporting the repair and remodeling processes in response to injury.

  • What are the primary functions of C57BL/6 Mouse Lung Fibroblasts?

    The main functions of these fibroblasts include synthesizing extracellular matrix components like collagen and elastin, which maintain lung tissue architecture. They also play a significant role in wound healing, fibrosis, and lung tissue repair, especially after injury or inflammation.

  • How are lung fibroblasts involved in the development of pulmonary fibrosis?

    In pulmonary fibrosis, these fibroblasts become activated and differentiate into myofibroblasts, which produce an excess of extracellular matrix proteins. This leads to scarring or fibrosis in the lung, resulting in impaired respiratory function and lung stiffness.

  • What are C57BL/6 Mouse Lung Fibroblasts used for in research?

    These cells are utilized in research focused on lung tissue repair, fibrosis, inflammation, and wound healing. They are also used in drug discovery for developing therapies targeting lung diseases, including treatments aimed at reducing fibrotic tissue formation.

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