C57BL/6 Mouse Proximal Tubular Epithelial Cells

Description

C57BL/6 Mouse Proximal Tubular Epithelial Cells are isolated from the kidney cortex of C57BL/6 mice. These cells form the lining of the proximal tubules and play a central role in reabsorption of solutes, water, and nutrients from the glomerular filtrate. They are key players in renal physiology and are implicated in acute kidney injury, nephrotoxicity, and chronic kidney disease. Proximal tubular epithelial cells serve as an important model for studying renal transport, oxidative stress, and inflammation. These cells express of epithelial markers such as aquaporin-1 (AQP1), Na+/K+-ATPase, and cytokeratin. Repeated freeze-thaw cycles should be avoided in vitro to preserve cell viability and functional phenotype. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from mycoplasma, fungi, yeast, and bacteria.