CD-1 Mouse Spleen Fibroblasts

Description

CD-1 Mouse Spleen Fibroblasts are primary cells isolated from the spleen tissue of adult CD-1 mice. These cells are a subtype of fibroblasts. They play a structural role in the splenic stroma and contribute to the formation of the extracellular matrix. Following isolation, cells are cryopreserved at early passage to ensure biological integrity and minimize senescence. In culture, these fibroblasts exhibit a spindle-shaped morphology and adhere to the culture surface. Spleen fibroblasts are non-hematopoietic stromal cells that support lymphoid architecture and influence immune cell homeostasis via cytokine and chemokine production. Studies have shown that splenic fibroblasts can modulate immune responses during chronic inflammation and autoimmune diseases such as systemic lupus erythematosus. In vitro, these fibroblasts retain immunomodulatory properties and show positive expression of stromal markers including PDGFRα and Sca-1. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.