CD57 Mouse Meningeal Cells

Description

CD57 Mouse Meningeal Cells are isolated from the meningeal tissue of neonatal or young adult C57BL/6 mice. These cells include a heterogeneous population comprising fibroblasts, macrophages, and vascular-associated cells that play key roles in the structure and immune surveillance of the central nervous system (CNS). In vitro, they secrete extracellular matrix proteins and cytokines, and they contribute to the formation of the meningeal barrier and the regulation of neuroinflammation. In culture, these cells exhibit adherent growth with fibroblast-like morphology and form networks contributing to ECM deposition. These cells are particularly valuable in research on neurodevelopment, multiple sclerosis, and CNS injury, given their involvement in leukocyte recruitment and neuroimmune interactions. Meningeal cells express markers such as fibronectin and vimentin, and certain populations may express CD44 and ICAM-1, depending on their activation status. These cells should not be repeatedly freeze-thawed. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.