For research use only
| Cat No. | ABC-TC0152 |
| Product Type | Human Colon Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colon Adenocarinoma |
| Product Code | Colo 205; CoLo 205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 |
COLO-205 Cell Line from AcceGen is a colon adenocarcinoma model widely applied in gastrointestinal cancer biology, drug discovery, and biomarker research.
COLO‑205 is a human colorectal adenocarcinoma cell line derived from the ascitic fluid of a 70-year-old male with Dukes’ stage D colon cancer. The cells exhibit an epithelial-like morphology, growing as both loosely adherent monolayers and suspended spherical aggregates. These markers occur in monosomic, disomic, and trisomic conditions, although most are present as monosomic. COLO‑205 expresses epithelial markers such as keratin and secretes low levels of carcinoembryonic antigen (CEA). These cells are tumorigenic in nude mice, forming moderately differentiated adenocarcinomas that reflect human colon cancer histology. Genetically, they are microsatellite stable (MSS) and harbor mutations in key genes including APC, BRAF, CTNNB1, and TP53. A mutation in E-cadherin contributes to enhanced tumorigenicity and altered adhesion. Although COLO‑205 cells do not readily grow in soft agar, they remain a robust model for studying colorectal cancer biology. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.
| Product Code | Colo 205; CoLo 205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 |
| Species | Human |
| Cat.No | ABC-TC0152 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent and Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colon Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
COLO‑205 is widely used in gastrointestinal cancer research, particularly in the study of colorectal adenocarcinoma. Its defined genetic background and stable microsatellite status make it highly suitable for investigating cancer signaling pathways, drug resistance mechanisms, and mutation-specific responses to therapy. The cell line is frequently employed in apoptosis studies, especially those involving TRAIL-induced cell death. COLO‑205 is also used in xenograft models, making it valuable for in vivo evaluation of therapeutic efficacy and tumor progression. Due to its epithelial characteristics and consistent growth behavior, it is a dependable model for screening anti-cancer agents and evaluating biomarker candidates in colorectal cancer.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
