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| Product Code | DL40 |
| Species | Human |
| Cat.No | ABC-TC0210 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoid |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Anaplastic Large Cell Lymphoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
DL-40 is a human Ki-1-positive T-cell lymphoma cell line that was originally isolated from the peripheral blood of a 64-year-old female patient with aggressive large cell lymphoma. DL-40 exhibits lymphoblast morphology and suspension culture properties with or without forming clumps, featuring abundant cytoplasm encompassing large, round, or multiple nuclei that exhibited a positive reaction to acid phosphatase. DL-40 expresses a Ki-1 antigen (CD30), E+, CD2+, CD4+, CD45+, and Ia+; it’s positive for acid phosphatase and negative for peroxidase, Epstein-Barr virus nuclear antigen, and HTLV-1 antigen. The karyotype of DL-40s shows complex hyperdiploid abnormalities.
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With its unique attributes, the DL-40 cell line assumes a pivotal role in unraveling the intricacies of Ki-1-positive non-Hodgkin’s lymphoma biology. Serving as a robust in vitro model, it facilitates the exploration of key determinants influencing tumor survival within the context of anaplastic large-cell lymphoma. Moreover, its utility extends to investigating the mechanisms underlying lymph node metastasis and propels advancements in therapeutic modalities, ultimately contributing to the targeted development of innovative drugs.
