For research use only
| Cat No. | ABC-TC0222 |
| Product Type | Human Uterine Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Uterus |
| Disease | Cancer |
| Product Code | DoTc2-4510; DOTC2-4510; DOTC24510; DoTc2 |
Organ: cervix Disease: carcinoma
DoTc2 4510 cell line is a human cervical carcinoma cell line originally isolated from the cervix of a female with cervical carcinoma, with specified DoTc2 4510 media requirements for in vitro culture. This epithelial-derived line exhibits adherent culture properties. The stemline karyotype model number of DoTc2 4510 is 62 with a range from 57 to 75. The cells have mutations in TP53, PIK3CA, and CDKN2A. DoTc2 4510 cell line expresses HPV16 E6 and E7 oncoproteins. These cells also express MMP-9 and CADM1. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | DoTc2-4510; DOTC2-4510; DOTC24510; DoTc2 |
| Species | Human |
| Cat.No | ABC-TC0222 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Uterus |
| Disease | Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Uterine Cancer Cell Lines |
DoTc2 4510 cells serve as a cervical adenocarcinoma model to investigate HPV16-driven oncogenesis and therapy resistance mechanisms. They enable in vitro chemotherapy sensitivity screening and radiation sensitization studies through analysis of viral oncoprotein E6/E7-mediated p53 degradation and telomerase activation. This system facilitates validation of targeted therapies against EGFR/PI3K pathways and analysis of metastatic behavior in 3D organoid co-cultures, supporting preclinical research on cervical cancer.
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