HighQC Human iPSC-Derived GABAergic neurons PSEN1 M146L/M146L

Description

HighQC Human iPSC-Derived GABAergic neurons PSEN1 M146L/M146L are human iPSC-derived GABAergic neurons generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Alzheimer’s disease research involving central nervous system biology. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a homozygous PSEN1 M146L missense mutation on both alleles and represents a familial Alzheimer’s disease (FAD)-associated presenilin-1 mutation model in vitro, without recapitulating full clinical phenotypes. They display functional properties consistent with GABAergic neurons. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.