HighQC Human iPSC-Derived Microglia APOE 4/3 C112R/WT

Description

HighQC Human iPSC-Derived Microglia APOE 4/3 C112R/WT are human iPSC-derived microglia generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Alzheimer’s disease research in CNS-resident myeloid lineage. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a heterozygous APOE4/APOE3 genotype, corresponding to the Cys112Arg (C112R) substitution on the APOE4 allele paired with a wild-type APOE3 allele, providing an intermediate Alzheimer’s disease genetic risk background, without implying a fixed clinical phenotype. They exhibit microglia-like immune functions characteristic of CNS-resident macrophages, supporting neuroimmune research. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.