HighQC Human iPSC-Derived Microglia P2RY12 null/null

Description

HighQC Human iPSC-Derived Microglia P2RY12 null/null are human iPSC-derived microglia generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Alzheimer’s disease-associated microglial dysfunction research involving the CNS-resident myeloid lineage. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a homozygous P2RY12 null mutation on both alleles, modeling complete loss of P2RY12-dependent homeostatic microglial signaling relevant to Alzheimer’s disease-associated neuroinflammation, without implying a fixed clinical phenotype. They exhibit microglia-like immune functions characteristic of CNS-resident macrophages, supporting neuroimmune research. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.