HighQC Human iPSC-Derived Microglia APOE 4/4 C112R/C112R

Description

HighQC Human iPSC-Derived Microglia APOE4/4 (C112R/C112R) are generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Alzheimer’s disease research in CNS-resident myeloid lineage. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. These cells carry a homozygous APOE ε4/ε4 (C112R/C112R) genotype with Cys112Arg substitution on both alleles, providing a defined disease-associated genetic background without implying a specific clinical phenotype. They exhibit microglia-like immune functions characteristic of CNS-resident macrophages, supporting neuroimmune research. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.