HighQC Human iPSC-Derived Motor Neurons FUS P525L/P525L

Description

HighQC Human iPSC-Derived Motor Neurons FUS P525L/P525L are human iPSC-derived motor neurons generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for amyotrophic lateral sclerosis (ALS) and FUS-associated neurodegenerative disease research. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a homozygous FUS P525L missense mutation on both alleles, modeling FUS proteinopathy relevant to early-onset familial ALS, without implying a fixed clinical phenotype. They retain neuronal lineage characteristics associated with motor neuron models. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.