For research use only
| Cat No. | ABC-TC0431 |
| Product Type | Human Colon Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Rectum |
| Disease | Rectal Adenocarinoma |
| Product Code | HT55 |
HT-55 colon cancer cells from rectal adenocarcinoma show well-differentiated morphology, key colorectal mutations, useful for pathogenesis and therapy.
The HT-55 is a human colorectal adenocarcinoma cell line derived from the rectum of a 54-year-old Caucasian female patient. These cells display an epithelial morphology, grow in adherent clumps that resemble columnar epithelium with a clear border and are representative of poorly differentiated colon cancer. HT-55 cells exhibit chromosomal instability and a near-triploid karyotype, common in aggressive colorectal tumors. As a rectal adenocarcinoma model, this cell line carries multiple colorectal cancer characteristic gene mutations including APC gene (p. Gln1131Ter, p. Gln1303Ter, p. Arg1463Ser), TP53 gene (p. Arg213Leu), BRAF gene (p. Asn581Tyr) and DNMT3A gene (p. Lys241Ter). HT-55 cells are tumorigenic in xenograft models and show moderate metastatic potential. Their molecular and phenotypic features make them a valuable model for studying drug resistance, tumor heterogeneity, and colorectal cancer progression.
| Product Code | HT55 |
| Species | Human |
| Cat.No | ABC-TC0431 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Rectum |
| Disease | Rectal Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
HT-55 cells are widely utilized in colorectal cancer research for investigating tumor biology, chemotherapy resistance, and signaling pathways affected by KRAS and TP53 mutations. They are suitable for evaluating small molecule inhibitors, developing biomarker assays, and testing immunotherapy combinations. HT-55 also supports tumor growth studies in animal models.
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