For research use only
| Cat No. | ABC-TC0157 |
| Product Type | Human Colon Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colon Adenocarinoma |
| Product Code | COLO #320HSR COLO320HSR; COLO 320 HSR; COLO-320-HSR; COLO 320 (HSR); COLO-HSR; Colorado 320 Homogeneously Staining Regions |
COLO-320HSR cell line is a human colorectal cancer model widely used for drug testing, tumor biology, and gene regulation research applications.
The COLO-320HSR cell line was derived from the same patient as COLO-320DM but exhibits distinct biological characteristics, growing as adherent epithelial cells rather than floating aggregates. Originating from a metastatic lymph node of a 55-year-old female with poorly differentiated colorectal adenocarcinoma, these cells display classic malignant features including uncontrolled proliferation and anchorage-independent growth. Morphologically, they appear as polygonal epithelial cells forming monolayer sheets. Karyotype analysis reveals chromosomal abnormalities including del(1p), +7, +12, and del(18q) – alterations associated with advanced colorectal cancer. Unlike its parental line, it is adherent and characterized by marker chromosomes with homogeneously staining regions (HSR) and double minutes (DM) at very low levels, reflecting MYC amplification. Gene expression profiling shows TP53 mutation (R273C), and APC mutation. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.
| Product Code | COLO #320HSR COLO320HSR; COLO 320 HSR; COLO-320-HSR; COLO 320 (HSR); COLO-HSR; Colorado 320 Homogeneously Staining Regions |
| Species | Human |
| Cat.No | ABC-TC0157 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colon Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
COLO-320HSR cells are particularly valuable for studying adherent colorectal cancer models with neuroendocrine features, serving as an excellent platform for drug screening, metastasis research, and investigation of MYC-driven oncogenesis. Their APC status makes them ideal for studying alternative Wnt signaling pathways in CRC. Researchers utilize this line for investigating cancer stem cell properties, epithelial-mesenchymal transition, and developing targeted therapies against aggressive colorectal cancer subtypes. The adherent growth characteristics facilitate high-throughput screening applications not possible with suspension-growing variants.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
