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Primary Cells

Human Allergy-related Peripheral Blood Mononuclear Cells

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Specificity of allergen of interest is verifiable, with common and rare allergies accessible. Examples of allergies include: Animal (cat, dog), Environmental (Pollen, Seasonal, Birch, Dust Mite, Rye Grass), Food (Egg, Fish, Shrimp, Milk, Peanut, Meat, Nut), Insect Bite (Bee, Wasp).
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Allergy-related Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4356
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Allergy
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Allergy-related Peripheral Blood Mononuclear Cells are a heterogeneous population of immune cells derived from the peripheral blood of individuals with allergic conditions, primarily including lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs are small, round cells. Allergy-related PBMCs play a central role in hypersensitivity reactions. Th2 cells drive allergic inflammation by secreting IL-4, IL-5, and IL-13, which promote IgE production by B cells and activate eosinophisl. Regulatory T (Treg) cells may exhibit impaired function in allergies, failing to suppress aberrant immune responses.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Allergy-related Peripheral Blood Mononuclear Cells can be used to analyze the activation characteristics of Th2 immune response, the regulatory mechanism of IgE production, and immune tolerance defects. They can also be used to evaluate the immunomodulatory effects of anti-allergic drugs (such as glucocorticoids, biological targeted agents), or to test the in vitro effectiveness of new immunotherapies.

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