For research use only
| Cat No. | ABC-TC3497 |
| Product Type | Vascular Cells |
| Cell Type | Smooth Muscle Cell |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Aorta |
| Disease | Normal |
| Storage | Liquid Nitrogen |
Primary Human Aortic Smooth Muscle Cells were initiated from normal human descending aorta tissue.
Human Aortic Smooth Muscle Cells (HASMCs), Descending Aorta are primary cells isolated from human descending aorta tissue and cryopreserved at low passage. Belonging to the smooth muscle cell type, these cells exhibit characteristic spindle-shaped morphology and grow as adherent monolayers. These cells play a crucial role in maintaining the aorta’s structure and function, regulating vascular tone for blood pressure control, and are central to understanding the role of smooth muscle in aortic diseases. Pathologically, these cells are implicated in cardiovascular diseases including atherosclerosis, aortic aneurysms, and hypertension. HASMCs express smooth muscle α-actin. Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | Human Descending Aorta Smooth Muscle Cells, Descending Aortic SMCs, Human Aortic SMCs Descending, Aorta Smooth Muscle Cells Human Descending, HAoSMCs Descending |
| Species | Human |
| Cat.No | ABC-TC3497 |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Smooth Muscle Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Aorta |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Vascular Cells |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Human Aortic Smooth Muscle Cells (HASMCs) from the descending aorta serve as a physiologically relevant in vitro model to study vascular pathogenesis in conditions like hypertension, aortic aneurysm, and atherosclerosis. Their responsiveness to TGF-β signaling and MMP activity enables detailed investigation of extracellular matrix remodeling. Researchers can utilize them to reveal mechanisms of medial layer degradation and hypercontractility, which enables therapeutic screening of vasodilators and stent coatings targeting arterial stiffness and plaque destabilization in cardiovascular diseases.
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