Human Brachiocephalic Artery Smooth Muscle Cells

Description

Human Brachiocephalic Artery Smooth Muscle Cells are primary cells isolated from human brachiocephalic artery tissue. They are smooth muscle cells, obtained from either healthy or diseased tissues relevant to arterial conditions like atherosclerosis. They are cryopreserved at early passage to maintain their native properties. These cells exhibit spindle-shaped morphology and adherent growth in monolayer. Functionally, they are crucial for regulating arterial tone and modulating arterial stiffness and smooth muscle function, thus controlling blood pressure and blood flow. Abnormalities in these cells can lead to various cardiovascular disorders, with atherosclerosis being a prime example. Robust expression of alpha-smooth muscle actin (α-SMA) is confirmed, validating their vascular smooth muscle identity. While maintaining normal karyotype in healthy-derived cells, these primary cells have limited expansion capacity and require specialized culture conditions to preserve their artery-specific properties. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.