Human Bronchial Epithelial Cells without RA

Description

Human Bronchial Epithelial Cells without RA are primary cells typically isolated from the bronchial mucosa. They consist of basal cells (expressing CK5/CK14, with stem cell properties), goblet cells (secreting mucins such as MUC5AC), and ciliated cells (clearing mucus through ciliary beating). Human Bronchial Epithelial Cells express tight junction proteins (e.g., Occludin, Claudin-3, ZO-1) to maintain epithelial barrier integrity. They can also initiate basic innate defense responses against inhaled pathogens, although mucociliary differentiation is limited without RA. Additionally, these bronchial cells participate in immune responses by secreting cytokines (e.g., IL-8, TNF-α) and expressing pattern recognition receptors (e.g., TLR4). The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.