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Primary Cells

Human Fibroblast-Like Synoviocyte Normal Tissue, Adult

  • For research use only

Cat No.

ABC-TC3619
Product Type

Synoviocytes
Cell Type

Fibroblast-Like
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen

Human Normal HFLS synthesize ECM and lubricate joints; under RA stimuli, they secrete IL-6 and MMPs, modeling inflammation and pannus formation.

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  • Human-Fibroblast
  • Human Fibroblast-Like Synoviocyte Normal Tissue, Adult
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Home | Primary Cells | Human Primary Cells | Motion System Primary Cells | Human Fibroblast-Like Synoviocyte Normal Tissue, Adult

Description

Human Fibroblast-Like Synoviocyte Normal Tissue, Adult are isolated from healthy adult synovial tissue, providing physiologically relevant models for joint biology and musculoskeletal research. These cells exhibit characteristic spindle-shaped morphology and express typical synoviocyte markers including CD55, VCAM-1, and cadherin-11, while maintaining their unique capacity to produce hyaluronic acid and lubricin. The FLS display normal proliferative activity and matrix remodeling functions, with balanced expression of MMPs/TIMPs and inflammatory mediators (PGE2, IL-6). Their preserved synovial fibroblast phenotype makes them ideal controls for arthritis studies or tissue engineering applications. These human fibroblast cells serve as a reliable primary fibroblast model for investigating cellular signaling, extracellular matrix dynamics, and joint tissue homeostasis in both basic and translational research.

Product Code

HFLS
Species

Human
Cat.No

ABC-TC3619
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast-Like
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Synoviocytes
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Application

  • These normal FLS serve as critical controls in rheumatoid arthritis research for comparative studies with diseased counterparts. Researchers utilize them to investigate synovial joint homeostasis and mechanisms of cartilage protection. Additionally, they support tissue engineering applications for joint repair through their ECM production capabilities. Their physiological response patterns make them suitable for screening anti-inflammatory compounds and studying mechanotransduction in synovial tissues.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Quality Control Report

  • Test Item
  • Flow Cytometry
  • Flow Cytometry
  • Flow Cytometry
  • Result

  • Flow cytometry plot of Human Fibroblast-Like Synoviocyte Normal Tissue, Adult, showing vimentin expression to be 94.1%.

    The percentage of Vimentin expression in HFLS Cell Line was detected by flow cytometry to be approximately 94.1%.

  • Flow cytometry plot of Human Fibroblast-Like Synoviocyte Normal Tissue, Adult, showing vimentin CD90 to be 95.9%.

    The percentage of CD90 expression in HFLS Cell Line was detected by flow cytometry to be approximately 95.9%.

  • Flow cytometry plot of Human Fibroblast-Like Synoviocyte Normal Tissue, Adult, showing vimentin fibronectin to be 99.1%.

    TThe percentage of Fibronectin expression in HFLS Cell Line was detected by flow cytometry to be approximately 99.1%.

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