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Human Kidney Fibroblasts

Product Name

Human Kidney Fibroblasts

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Cat.No

ABC-TC5519

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human kidney fibroblasts (HKF), or renal fibroblasts, are mesenchymal cells that display spindle-shaped morphology. They can be found in renal cortical interstitium and play an important role in maintaining extracellular matrix (ECM) homeostatic by controlling ECM production and degradation. Abnormal kidney fibroblast proliferation can lead to kidney ECM accumulation and often lead to renal fibrosis, which may develop into chronic kidney disease. Kidney interstitial fibroblast also plays a key role in endocrine control. They are the source of erythropoietin (EPO), a glycoprotein hormone that is central for proliferation and differentiation of erythroid progenitor cells. A well-functioned renal cortical fibroblast can protect human against anaemia.

Why Choose Human Kidney Fibroblasts from AcceGen?
AcceGen Human kidney fibroblasts are collected from healthy adult renal tissue. Kidney tissue was isolated into single cells and the fibroblasts were extracted and cultured into high purity.
Kidney fibroblasts are cryopreserved at passage one for best viability and culture efficiency. They can further expand for 3-5 passages in cell culture media kit following suggested protocols in technical sheet provided by AcceGen.

All kidney fibroblasts have passed QC test and been confirmed negative for HIV-1, HIV-2, Hepatitis B and Hepatitis C as detected by serology or PCR. Cells are also tested negative for mycoplasma and other detectable microbial contaminations.

Disease

Normal

Source Organ

Kidney

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only
Human kidney cortex fibroblast can be used as a good model for studying renal disease, endocrine regulation, and ECM homeostasis. Furthermore, they may be used to study the development of kidney, assay cell interactions or the generation of cell derivatives.

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved in dry ice for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Fibroblast

Growth Mode

Adherent

Product Type

Renal Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What are Human Kidney Fibroblasts (HKFs)?

    Human Kidney Fibroblasts (HKFs) are specialized cells derived from the connective tissue of the human kidney. They play a crucial role in the structural support of the kidney and are involved in the production of extracellular matrix proteins.

  • How are Human Kidney Fibroblasts (HKF) typically cultured?

    HKFs are cultured in fibroblast growth medium supplemented with specific growth factors. The optimal culture conditions include a temperature of 37°C, 5% CO2, and a humidified atmosphere to ensure cell viability and proliferation.

  • How do HKFs contribute to the study of renal fibrosis?

    HKFs are instrumental in research on renal fibrosis as they are the primary cells responsible for the excessive production of extracellular matrix components in response to kidney injury. This makes them an ideal model to study the pathogenesis of fibrosis and test anti-fibrotic drugs.

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