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Primary Cells

Human Mature Hepatocytes, Non-Plateable

  • For research use only

Cat No.

ABC-TC3893
Product Type

Hepatic Cells
Cell Type

Hepatocyte
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Human Mature Hepatocytes, Non-Plateable are used for hepatic metabolism, drug toxicity testing, and non-adherent culture systems in liver research.

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  • Human Mature Hepatocytes, Non-Plateable
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Mature Hepatocytes, Non-Plateable

Description

Human Mature Hepatocytes, Non-Plateable are typically isolated from the adult liver tissue. Hepatocytes exhibit a polyhedral shape with abundant eosinophilic cytoplasm due to high organelle content, prominent round nuclei, and often binucleation. These epithelial cells perform essential metabolic functions: glucose homeostasis (glycogen storage/gluconeogenesis), lipid metabolism (VLDL secretion), bile acid synthesis, and xenobiotic detoxification (Phase I-III metabolism). Key functional markers include albumin (ALB) and asialoglycoprotein receptor 1 (ASGR1), which are commonly used to characterize mature hepatocytes. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.

Product Code

Human Mature Hepatocytes, Non-Plateable, Suspension Hepatocytes, Non-Adherent Hepatocytes, Cryopreserved Mature Hepatocytes
Species

Human
Cat.No

ABC-TC3893
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Hepatocyte
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Hepatic Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Mature Hepatocytes, Non-Plateable can be used for hepatotoxicity testing, enabling accurate prediction of drug-induced liver injury (DILI) by assessing cytochrome P450-mediated metabolism, bile acid transport, and mitochondrial dysfunction. In pharmacokinetic studies, these cells model first-pass metabolism and drug-drug interactions more reliably than immortalized cell lines. Additionally, they are crucial for studying viral hepatitis (HBV/HCV), as they support full viral life cycles, facilitating antiviral drug screening.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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