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| Product Code | HM |
| Species | Human |
| Cat.No | ABC-TC3704 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Microglia |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Nervous Cells |
| Key Features | -Backed by AcceGen advanced technology |
Human Microglia, a type of glial cell, are isolated from the human brain tissue. When cultured in vitro, these cells exhibit adherent growth. As the primary immune cells of the brain, they maintain a quiescent phenotype in the normal central nervous system (CNS), capable of expressing CD86 and CD40. Upon injury to the CNS, microglia transition to an active phenotype, releasing cytokines and reactive oxygen species. Human Microglia play a crucial role in neuronal development and neurodegenerative diseases. Beyond their immune surveillance function, human microglia play essential roles in synaptic pruning during neural development and contribute to the pathogenesis of various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Human Microglia can be used to test new therapies targeting neuroinflammation. It can be used to analyze the functions of risk genes such as TREM2 and CD33 in gene editing studies. It can also be co-cultured with neurons to simulate the neural-immune interaction mechanism.
Human Microglia are a type of myeloid cell that reside in the parenchyma of the healthy central nervous system (CNS), accounting for 10 – 15% of all cells in the brain. They act as the primary active immune defense in the CNS, constantly monitoring the microenvironment and responding to noxious stimuli. Microglia play a crucial role in maintaining brain homeostasis by clearing tissue debris, damaged cells, or microbes, and scavenging for plaques, damaged neurons, and infectious agents.
When programmed cell death occurs or the CNS is injured, microglia act as brain macrophages to clear tissue debris, damaged cells, or microbes. They are highly sensitive to pathological changes and work to regulate brain homeostasis during development and in adult brains, both under physiological and pathological conditions.
Human Microglia from AcceGen are characterized by immunofluorescence with antibodies to several markers, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin. These markers help in identifying and confirming the presence and purity of microglial cells.
Human Microglia are widely used in research because they play a vital role in the immune defense of the CNS and are involved in clearing debris and pathogens. They are also essential for studying the regulation of brain homeostasis, both during development and in adult brains, under normal and pathological conditions. This makes them valuable for understanding neurological diseases and developing potential treatments.
Researchers choose Human Microglia from AcceGen because these cells are characterized by specific immunofluorescence markers, ensuring high quality and purity. AcceGen provides reliable and well-characterized microglial cells that are essential for accurate and effective research in neuroscience and immunology.
