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Primary Cells

Human Ovarian Fibroblasts

  • For research use only

Cat No.

ABC-TC3741
Product Type

Female Reproductive Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Ovarian
Disease

Normal
Storage

Liquid Nitrogen

Human ovarian fibroblasts with spindle morphology become cancer-associated fibroblasts secreting growth factors and enzymes promoting tumor progression.

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  • Human Ovarian Fibroblasts
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Home | Primary Cells | Human Primary Cells | Reproductive System Primary Cells | Human Ovarian Fibroblasts

Description

Human Ovarian Fibroblasts are primary cells isolated from healthy human ovarian tissue and cryopreserved at early passages to retain native characteristics. These fibroblasts exhibit spindle-shaped morphology and adhere to culture flasks in a monolayer. Ovarian fibroblasts play a key role in maintaining the structural integrity of ovarian tissue and are involved in extracellular matrix production and tissue remodeling. In the presence of ovarian cancer cells, these fibroblasts undergo significant structural and biochemical changes, becoming cancer-associated fibroblasts (CAFs). This transformation leads to the secretion of various peptides, including growth factors, chemokines, collagens, and matrix-modifying enzymes, fostering a pro-tumorigenic and immunosuppressive microenvironment that promotes cancer progression and metastasis. Immunophenotypically, they express vimentin and fibroblast-specific protein 1 (FSP1). These cells serve as an essential model for studying ovarian stromal biology, tumor microenvironment interactions, and fibrotic disease mechanisms.

Product Code

Human Ovarian Fibroblasts, Ovarian Stromal Fibroblasts Human, HOFs, Ovary Connective Tissue Fibroblasts, Human Ovarian Stromal Cells
Species

Human
Cat.No

ABC-TC3741
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Ovarian
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Female Reproductive Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Ovarian Fibroblasts are valuable for their role in promoting cancer progression and invasiveness. They serve as essential in vitro models for studying the pathophysiology of ovarian diseases, providing mechanistic insights. Moreover, these fibroblasts prove to be indispensable tools for establishing in vitro disease models, supporting high-throughput and high-content screening approaches, thereby advancing research and potential therapeutic interventions.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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