Human Ovarian Fibroblasts are primary cells isolated from healthy human ovarian tissue, typically utilized at early passages. These fibroblasts exhibit a spindle-shaped morphology and adhere to culture flasks in a monolayer. They play a pivotal role in maintaining ovarian tissue homeostasis by synthesizing extracellular matrix components and facilitating wound healing processes. In the presence of ovarian cancer cells, these fibroblasts undergo significant structural and biochemical changes, becoming cancer-associated fibroblasts (CAFs). This transformation leads to the secretion of various peptides, including growth factors, chemokines, collagens, and matrix-modifying enzymes, fostering a pro-tumorigenic and immunosuppressive microenvironment that promotes cancer progression and metastasis. Immunophenotypically, they express vimentin and fibroblast-specific protein 1 (FSP1), confirmed via immunocytochemistry. Karyotyping reveals a normal chromosomal profile. These cells are negative for HIV-1, HIV-2, HTLV-I, and HTLV-II, ensuring biosafety. Their unique properties make them invaluable for studying tumor-stroma interactions and the tumor microenvironment.
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