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Primary Cells

Human Pancreatic Epithelial Cells

  • For research use only

Cat No.

ABC-TC3744
Product Type

Pancreatic Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Storage

Liquid Nitrogen

Analyze Human Pancreatic Epithelial Cells to model exocrine networks, study injury responses, and evaluate digestive enzyme regulation in vitro.

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  • Human Pancreatic Epithelial Cells
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Epithelial Cells

Description

Human Pancreatic Epithelial Cells are primary epithelial cells isolated from healthy adult pancreatic tissue via enzymatic digestion and selective adherence protocols. These cells constitute a fundamental component of the exocrine pancreas and provide a physiologically relevant in vitro system to model pancreatic epithelial biology. Morphologically, they display a characteristic cobblestone appearance and grow as adherent monolayers. During pancreatic development, the epithelial compartment undergoes differentiation into acinar, ductal, and endocrine lineages, with endocrine progenitors emerging through delamination to form islets of Langerhans. These cells express epithelial and ductal lineage markers including cytokeratin-19 (CK19), E-cadherin, and epithelial cell adhesion molecule (EpCAM), while lacking expression of endocrine hormones such as insulin and glucagon. Cells are cryopreserved at low passage to preserve primary phenotype and functionality. Given their origin and phenotype, these cells are widely utilized for modeling pathophysiological processes underlying pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis.

Species

Human
Cat.No

ABC-TC3744
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Pancreatic Epithelial Cells are valuable tools for research in pancreatic development, epithelial cell biology, and carcinogenesis. They are widely used in models of chronic pancreatitis, pancreatic fibrosis, and PDAC initiation. Researchers also employ these cells for drug screening, toxicology testing, and studying EMT and cytokine signaling in pancreatic inflammation and tumor progression.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Pancreatic Epithelial Cells, and how are they obtained?

    Human Pancreatic Epithelial Cells are cells derived from the epithelial tissue of the pancreas. They are typically isolated from donor pancreatic tissue using enzymatic digestion and are cultured for research purposes.

  • What are the primary research applications for Human Pancreatic Epithelial Cells?

    These cells are commonly used in studies related to pancreatic diseases, including diabetes, pancreatic cancer, and pancreatitis. They are also used in drug testing, toxicology studies, and research on pancreatic function and regeneration.

  • How should Human Pancreatic Epithelial Cells be cultured?

    Human Pancreatic Epithelial Cells should be cultured in a specialized epithelial cell medium that supports their growth and function. The use of pre-coated surface may also be necessary to promote cell adhesion and proliferation.

  • What are the key differences between Human Pancreatic Epithelial Cells and islet cells?

    Human Pancreatic Epithelial Cells are primarily involved in the formation of ducts and the secretion of digestive enzymes, whereas islet cells (including beta cells) are responsible for hormone production, such as insulin. Each cell type has distinct roles and is used for different types of research.

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