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Primary Cells

Human Pancreatic Islets of Langerhans Cells

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The Human Pancreatic Islets of Langerhans Cell Culture was derived from Human Pancreas. All donors from which the cells were derived were pre-screened; donors tested negative for the usual blood donation infectious disease panel ABO/RH, Hepatitis B Surface Antigen, HIV1 and 2, Syphilis, hepatitis B Core, Human T Lymphocyte Virus 1 and 2, Hepatitis C […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Islets of Langerhans Cells
Species

Human
Cat.No

ABC-TC4286
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Langerhans Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreatic Islet
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Pancreatic Islets of Langerhans are derived from the human pancreas.These are primary, non-passaged cells typically used immediately after isolation or short-term culture. They do not proliferate significantly in vitro. They form dense clusters of cells within the pancreas, comprising different endocrine cell types. Pancreatic beta cells (or β cells), which function in insulin secretion, are the most abundant islet cell type, accounting for around 50–70% of human islet cells. There are also glucagon-secreting pancreatic alpha cells (or α cells), Delta cells (δ cells or D cells) secreting somatostatin, Epsilon cells (ε cells) secreting ghrelin, and pancreatic PP cells secreting polypeptides. Beta cells express insulin and transcription factors such as PDX1 and MAFA; alpha cells express glucagon and ARX; delta cells express somatostatin and HHEX. These markers can be detected via immunostaining or qPCR.These pancreatic cells collectively act to maintain glucose homeostasis and regulate other aspects of metabolism.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Uddin, M., Li, Y., Khan, H.Y., Muqbil, I., Aboukameel, A., Sexton, R.E., Reddy, S., Landesman, Y., Kashyap, T., Azmi, A.S. and Heath, E.I., 2021. Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells. International journal of molecular sciences, 22(13), p.6676.

Application

  • Human Pancreatic Islets of Langerhans Cells can be used as an in vitro cell model to study the pathogenesis of diabetes. These cells can also be used for the screening and development of hypoglycemic drugs.

Frequently Asked Questions

  • What is the source of Human Pancreatic Islets of Langerhans Cells?

    These cells are isolated from the pancreas of healthy human donors or patients with diabetes.

  • Can Human Pancreatic Islets of Langerhans Cells be used for diabetes research?

    Yes, they are ideal for studying insulin secretion, glucose metabolism, and diabetes-related mechanisms.

  • What culture medium is recommended for Human Pancreatic Islets of Langerhans Cells?

    A specialized pancreatic islet medium supplemented with appropriate growth factors is recommended.

  • Are Human Pancreatic Islets of Langerhans Cells suitable for drug discovery in diabetes treatments?

    Yes, these cells are commonly used in drug discovery and testing for potential diabetes therapies.

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