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Primary Cells

Human Pancreatic Islets of Langerhans Cells

  • For research use only

Cat No.

ABC-TC4286
Product Type

Pancreatic Cells
Cell Type

Langerhans Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreatic Islet
Disease

Normal
Storage

Liquid Nitrogen

Human Pancreatic Islets of Langerhans Cells contain alpha, beta, and delta cells, ideal for pancreas function, diabetes, and islet biology studies.

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  • Human Pancreatic Islets of Langerhans Cells
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic Islets of Langerhans Cells

Description

Human Pancreatic Islets of Langerhans cells are derived from the human pancreas. These are primary, non-passaged cells typically used immediately after isolation or short-term culture. They do not proliferate significantly in vitro. They form dense clusters of cells within the pancreas, comprising different endocrine cell types. Pancreatic beta cells (or β cells), which function in insulin secretion, are the most abundant islet cell type, accounting for around 50–70% of human islet cells. There are also glucagon-secreting pancreatic alpha cells (or α cells), Delta cells (δ cells or D cells) secreting somatostatin, Epsilon cells (ε cells) secreting ghrelin, and pancreatic PP cells secreting polypeptides. Beta cells express insulin and transcription factors such as PDX1 and MAFA; alpha cells express glucagon and ARX; delta cells express somatostatin and HHEX. These markers can be detected via immunostaining or qPCR. These pancreatic cells collectively act to maintain glucose homeostasis and regulate other aspects of metabolism. The islet cells, including the various pancreatic cell types like alpha, beta, and delta cells, make up the Langerhans islets of the pancreas and are crucial for regulating glucose levels within human islets.

Species

Human
Cat.No

ABC-TC4286
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Langerhans Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreatic Islet
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pancreatic Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human pancreatic islets are critical for diabetes research, including studies on insulin secretion, beta-cell dysfunction, and autoimmune destruction (type 1 diabetes). They serve as a model for drug screening (e. g., GLP-1 analogs, sulfonylureas), islet transplantation optimization, and stem cell-derived beta-cell differentiation. Additionally, they are used to investigate metabolic syndrome, obesity-related insulin resistance, and genetic disorders such as MODY (Maturity-Onset Diabetes of the Young).

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Uddin MH, Li Y, Khan HY, et al. Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells. Int J Mol Sci. 2021;22(13):6676. Published 2021 Jun 22. doi:10.3390/ijms22136676

Frequently Asked Questions

  • What is the source of Human Pancreatic Islets of Langerhans Cells?

    These cells are isolated from the pancreas of healthy human donors or patients with diabetes.

  • Can Human Pancreatic Islets of Langerhans Cells be used for diabetes research?

    Yes, they are ideal for studying insulin secretion, glucose metabolism, and diabetes-related mechanisms.

  • What culture medium is recommended for Human Pancreatic Islets of Langerhans Cells?

    A specialized pancreatic islet medium supplemented with appropriate growth factors is recommended.

  • Are Human Pancreatic Islets of Langerhans Cells suitable for drug discovery in diabetes treatments?

    Yes, these cells are commonly used in drug discovery and testing for potential diabetes therapies.

  • What is the cellular composition of Human Pancreatic Islets of Langerhans Cells, and can they be expanded in culture?

    Human Pancreatic Islets of Langerhans Cells consist of a functional mixed population of endocrine cells, primarily β cells and α cells, along with δ cells, PP cells, and ε cells. These cells cannot be passaged.

  • What are the islets of Langerhans?

    The islets of Langerhans, also known as pancreatic islets, are clusters of endocrine cells in the pancreas. They include α, β, δ, PP, and ε cells, each responsible for secreting specific hormones that regulate blood glucose and metabolism.

  • Which cells of islets of Langerhans secrete insulin?

    Insulin is secreted by the β (beta) cells within the islets of Langerhans. These cells play a central role in lowering blood glucose and maintaining metabolic homeostasis.

  • Where are the islets of Langerhans found?

    They are dispersed throughout the pancreas, primarily within the pancreatic tissue, and constitute the endocrine portion of the organ.

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