Human PB Neutrophils

Description

Human Peripheral Blood Neutrophils (PB Neutrophils) (human neutrophils) are primary immune cells isolated from human blood, representing the most abundant white blood cell type in circulation. These polymorphonuclear leukocytes exhibit a characteristic multi-lobed nucleus and granule-filled cytoplasm, containing antimicrobial proteins (e.g., myeloperoxidase, defensins) and enzymes critical for host defense. Neutrophils are the first responders to infection, utilizing key mechanisms including phagocytosis, reactive oxygen species (ROS) production, and neutrophil extracellular trap (NET) formation. They express surface markers such as CD66b and play pivotal roles in acute inflammation, bacterial/fungal infections, and autoimmune diseases. Although primary in origin, these human neutrophils provide a benchmark for comparing neutrophil cell line behavior and validating human neutrophil markers in functional and immunological studies. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.