Human Renal Mesangial Cells (HRMCs) are primary cells isolated from renal glomerular tissue of healthy human donors. These cells exhibit an epithelial-like morphology and adherent culture properties. Functionally, HRMCs are specialized pericytes located within the glomerulus, where they regulate glomerular hemodynamics through contractile activity and help maintain filtration efficiency by phagocytosing macromolecular debris. They actively synthesize and remodel the mesangial extracellular matrix, a process whose dysregulation is implicated in IgA nephropathy, diabetic nephropathy, and lupus nephritis. These cells express high levels of α-smooth muscle actin (α-SMA), fibronectin, and Thy-1, consistent with their pericytic and contractile phenotype. These cells are cryopreserved at early passages to maintain physiological functionality, and they exhibit limited proliferative capacity and sensitivity to repeated freeze-thaw cycles.
Inquiring Human Renal Mesangial Cells
We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research
