Rat Renal Mesangial Cells

Description

Rat Renal Mesangial Cells (RRMCs) are primary glomerular cells isolated from pathogen-free Sprague-Dawley rat kidneys, specifically from the mesangium of renal glomeruli. They play a central role in maintaining glomerular structure, supporting capillary loops, and regulating filtration surface area, reflecting cell signaling in renal mesangial cells. RRMCs exhibit characteristic stellate morphology and adherent growth. The cells express mesangial-specific markers such as α-smooth muscle actin and desmin. These cells are ideal for studying glomerular diseases, mesangial matrix synthesis, and the role of mesangial cells in kidney repair, including responses to inflammatory stimuli or nephrotoxins. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.