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Human Retinal Muller Cells

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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Retinal Muller Cells
Species

Human
Cat.No

ABC-TC133L
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Muller Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Ocular Cells

Description

Human Retinal Muller Cells are derived from the human retina. Following the primary culture, these cells are cryopreserved. Muller cells are the principal glial cells of the retina, extending across its entire thickness and providing structural and metabolic support to retinal neurons. They maintain homeostasis, regulate extracellular ion balance, remove neurotransmitters, and contribute to the blood-retinal barrier. Studies have shown that Muller cells are implicated in various retinal diseases, including diabetic retinopathy, retinal detachment, and age-related macular degeneration. Repeated freezing and thawing should be avoided during the culture process.

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Citation

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Application

  • Human Retinal Müller Cells are tools for studying the human retina and understanding retinal diseases. Müller cells play a critical role in retinal health, and their vulnerability is closely linked to photoreceptor cell pathology, particularly during aging. These cells are useful for research into the various, yet not fully understood, roles they play in retinal diseases. Investigating Müller cell functions and dysfunctions can provide insights into retinal disease mechanisms. Additionally, their ability to dedifferentiate into progenitor-like cells holds promise for future therapeutic approaches. A deeper understanding of the gliotic mechanisms underlying reactive Müller cells can aid in developing strategies that enhance their protective and regenerative properties while reducing their toxicity, potentially leading to more effective treatments for retinal disorders.

Frequently Asked Questions

  • What are Human Retinal Muller Cells and what is their primary function?

    Human Retinal Muller Cells are a type of mammalian retinal glial cell that play a crucial role in supporting the structural integrity of the retina. They provide structural support to the retinal cells and are involved in various pathological processes such as glaucoma and diabetic retinopathy.

  • How many cells are contained in each vial of Human Retinal Muller Cells?

    Each vial of Human Retinal Muller Cells contains at least 5×10^5 cells. This quantity ensures that researchers have a sufficient number of cells for various experimental applications, such as studying retinal structure and function, investigating disease mechanisms, and testing potential treatments. The high cell count per vial facilitates multiple assays or experiments, enhancing the efficiency and reliability of research outcomes.

  • What role do Muller cells play in retinal enviroment?

    Muller cells play a crucial role in maintaining and repairing the retinal environment. They respond to retinal injury and disease, contributing to the pathological processes of conditions such as glaucoma and diabetic retinopathy. By reacting to damage and supporting the retinal structure, they influence the progression and response to these diseases.

  • Why are Human Retinal Muller Cells useful for research?

    Human Retinal Muller Cells are useful for research because they are integral to understanding the cellular and molecular mechanisms underlying retinal health and disease. Studying these cells can provide insights into the development and progression of retinal diseases and aid in the development of new therapeutic strategies.

  • What are the typical research applications of Human Retinal Muller Cells?

    Typical research applications of Human Retinal Muller Cells include studies on retinal structure and function, investigations into the mechanisms of retinal diseases such as glaucoma and diabetic retinopathy, and the development and testing of new treatments for these conditions. They are also used in studies exploring the general physiology and pathology of the retinal environment.

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