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Primary Cells

Human Retinal Muller Cells

  • For research use only

Cat No.

ABC-TC133L
Product Type

Ocular Cells
Cell Type

Muller Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Storage

Liquid Nitrogen

Human retinal Muller glial cells support neurons, maintain homeostasis, and model retinal diseases; cryopreserved with careful handling advised.

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  • Human Retinal Muller Cells
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Retinal Muller Cells

Description

Human Retinal Müller Cells are specialized glial cells isolated from adult human retinal tissue and cryopreserved after primary culture. These cells exhibit elongated, radial morphology spanning the retinal layers and express characteristic markers such as glutamine synthetase, vimentin, and CRALBP. As the principal glial cells of the retina, Müller cells provide structural and metabolic support to retinal neurons, maintain homeostasis, regulate extracellular ion balance, clear neurotransmitters, and contribute to the integrity of the blood-retinal barrier. They are critically involved in the pathophysiology of retinal diseases including diabetic retinopathy, retinal detachment, and age-related macular degeneration (AMD). Human Müller cells serve as essential models for studying retinal disorders such as diabetic retinopathy, glaucoma, and AMD. To preserve their viability and functional properties, repeated freeze-thaw cycles should be avoided during culture.

Species

Human
Cat.No

ABC-TC133L
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Muller Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Ocular Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Retinal Müller Cells are widely used in retinal disease research to investigate cellular responses to oxidative stress, inflammation, and metabolic dysfunction. They serve as an in vitro model to study mechanisms underlying diabetic retinopathy, retinal degeneration, and gliosis. These cells are also utilized for drug screening targeting neuroprotection and anti-inflammatory pathways and to explore cell signaling, neurovascular interactions, and retinal regeneration. Co-culture systems with retinal neurons enable studies of cell-cell communication and retinal microenvironment modulation.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Retinal Muller Cells and what is their primary function?

    Human Retinal Muller Cells are a type of mammalian retinal glial cell that play a crucial role in supporting the structural integrity of the retina. They provide structural support to the retinal cells and are involved in various pathological processes such as glaucoma and diabetic retinopathy.

  • How many cells are contained in each vial of Human Retinal Muller Cells?

    Each vial of Human Retinal Muller Cells contains at least 5×10^5 cells. This quantity ensures that researchers have a sufficient number of cells for various experimental applications, such as studying retinal structure and function, investigating disease mechanisms, and testing potential treatments. The high cell count per vial facilitates multiple assays or experiments, enhancing the efficiency and reliability of research outcomes.

  • What role do Muller cells play in retinal enviroment?

    Muller cells play a crucial role in maintaining and repairing the retinal environment. They respond to retinal injury and disease, contributing to the pathological processes of conditions such as glaucoma and diabetic retinopathy. By reacting to damage and supporting the retinal structure, they influence the progression and response to these diseases.

  • Why are Human Retinal Muller Cells useful for research?

    Human Retinal Muller Cells are useful for research because they are integral to understanding the cellular and molecular mechanisms underlying retinal health and disease. Studying these cells can provide insights into the development and progression of retinal diseases and aid in the development of new therapeutic strategies.

  • What are the typical research applications of Human Retinal Muller Cells?

    Typical research applications of Human Retinal Muller Cells include studies on retinal structure and function, investigations into the mechanisms of retinal diseases such as glaucoma and diabetic retinopathy, and the development and testing of new treatments for these conditions. They are also used in studies exploring the general physiology and pathology of the retinal environment.

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Inquiring Human Retinal Muller Cells

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High Viability
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