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Human Villous Trophoblasts

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The trophoblast begins at the outer covering of the early blastocyst and provides the route of nourishment between the maternal endometrium and the developing embryo. The trophoblast adhesion to the uterine wall is the requisite first step of implantation and, subsequently, placentation. Human villous tryophoblasts (HVT) covering the villi of the placenta provide the surface […]
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Species

Human

Cat.No

ABC-TC3870

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Trophoblast

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Villous

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Female Reproductive Cells

Description

Human Villous TrophoblastsHuman villous trophoblasts (HVT) are primary cells isolated from human placental villi, typically obtained from healthy pregnancies. These cells represent the progenitor population of the placental villi and exhibit distinct morphological features, including mononuclear cytotrophoblasts that fuse to form multinucleated syncytiotrophoblasts. HVT cells are cryopreserved at earliest passage and are not recommended for long-term expansion due to their limited proliferative capacity. Functionally, HVT mediate nutrient exchange, secrete pregnancy-sustaining hormones such as human chorionic gonadotropin (hCG) and placental lactogen, and express chemokine receptors CXCR4 and CCR5. These characteristics position HVT as a critical model for studying placental development and gestational pathologies.

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Citation

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Application

  • Human villous trophoblasts offer versatile applications in scientific research. They serve as an ideal cellular platform for investigating cell differentiation and organogenesis while also support the development of disease models for high-throughput and high-content screening. These cells are invaluable for researchers studying the molecular mechanisms underlying human placental development and pathology, helping to illuminate key events in placental morphogenesis and trophoblast regulation within the villous environment.

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