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Immortalized Cell Lines

Immortalized Human Bone Marrow-Derived Mesenchymal Stem Cells

  • For research use only

Cat No.

ABC-H0029X
Product Type

Immortalized Cell Line
Cell Type

Mesenchymal Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Normal
Storage

Liquid Nitrogen

Advance Immortalized Human Bone Marrow-Derived Mesenchymal Stem Cells for regenerative medicine, osteogenesis, and multipotent differentiation studies.

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  • Immortalized Human Bone Marrow-Derived Mesenchymal Stem Cells
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Home | Immortalized Cell Lines | Immortalized Human Bone Marrow-Derived Mesenchymal Stem Cells

Description

Immortalized human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are generated from primary human MSCs by transduction with SV40 large T-Ag to extend their replicative lifespan without compromising key stem cell properties. Morphologically, they exhibit a typical spindle-shaped mesenchymal appearance and possess the ability to self-renew and differentiate into multiple mesenchymal lineages, including osteogenic, adipogenic, and chondrogenic lineages under appropriate conditions. They express MSC-specific markers such as CD73, CD90, and CD105. Due to their genetic stability, multilineage potential, and immunomodulatory functions, immortalized hBM-MSCs provide a reliable and renewable source for regenerative medicine, stem cell biology, and immunotherapy research. These cells are extensively used in models of bone repair, inflammation, and hematopoietic support.

Species

Human
Cat.No

ABC-H0029X
Product Category

Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Mesenchymal Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Immortalized Human Bone Marrow-Derived Mesenchymal Stem Cells (hMSCs) have versatile applications. These cells are valuable for studying the bone marrow microenvironment and exploring how environmental signals influence hematopoiesis. Additionally, they are also applied in regenerative medicine, gene-based therapeutic interventions, cell differentiation and gene regulation, as well as cell-based screening assays. Immortalized hMSCs serve as essential tools for various research areas with potential implications for therapeutic advancements.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Is it recommended to use this cell product for induced differentiation into bone or cartilage?

    After immortalization, mesenchymal stem cells often lose some of their original characteristics. The success rate of differentiating them into osteoblasts or chondrocytes is very low. Even when differentiation occurs, the results are significantly less effective compared to primary stem cells. Therefore, this product is not recommended for induced differentiation into bone or cartilage.

  • What method is used for the immortalization of these cells?

    For the Immortalized Human Bone Marrow-Derived Mesenchymal Stem Cells, we typically use the SV40 transfection method for immortalization. However, upon customer request, we can also use the hTERT method for transfection.

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High Viability
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To support a consistent result
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