Immortalized Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis

Description

Immortalized Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis (FLS-RA) is an immortalized human cell line derived from the synovial tissue of a rheumatoid arthritis (RA) patient. These cells exhibit spindle-shaped fibroblast-like morphology and maintain adherent growth properties in vitro. The karyotype of Immortalized FLS-RA is complex and abnormal, often demonstrating chromosomal instability similar to that observed in primary RA FLS cells, which correlates with aggressive proliferation and an invasive phenotype. These cells have been widely used to model RA pathogenesis, particularly for studing pannus formation, matrix degradation, and cytokine-mediated inflammatory responses. Immortalized FLS-RA cells are non-tumorigenic but display hyperplastic properties