Explore Products
Tumor Cell Lines

Jurkat, Clone E6-1

  • BSL

    1

  • 300
This is a clone of the Jurkat-FHCRC cell line, a derivative of the Jurkat cell line. The Jurkat cell line was established from the peripheral blood of a 14 year old boy by Schneider et al., And was originally designated JM.
Request Your Custom Quote Today

Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.

Get a Quote
  • High Purity Levels
  • Precision and Reliability
  • Customization Options
Product Code

JurkatE6-1; Jurkat E6-1; Jurkat, Clone E6-1; Jurkat Clone E6-1; Jurkat (clone E6-1); JURKAT E-6.1; JURKAT E-61; Jurkat-CloneE61; Jurkat-E6; Jurkat E6; J.E6-1; E6-1

Species

Human

Cat.No

ABC-TC0482

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Blood

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Lymphocytes Cell Lines

Description

Jurkat, Clone E6-1Jurkat, Clone E6-1 is a human acute T-cell leukemia cell line originally established from the peripheral blood of a 14-year-old male patient with T-cell lymphoblastic leukemia. This suspension-growing lymphoblast-like cell line exhibits rapid proliferation. Cytogenetic analysis reveals a pseudodiploid karyotype (modal chromosome number 46) with recurrent abnormalities including deletions in chromosomes 2p21-p23 and 18p11.2, alongside mutations such as the TEL-JAK2 fusion gene and a frameshift mutation in Syk kinase that abolishes protein expression. The cells express CD3 surface markers and demonstrate interleukin-2 (IL-2) production. While primarily utilized for in vitro research, this cell line has been employed in subcutaneous xenograft models of leukemia.

View Product Image

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • Jurkat, Clone E6-1 cells are used to investigate T-cell receptor signaling pathways, including CD3/CD28 co-stimulation and calcium-dependent NFAT activation. These cells serve as models for studying HIV latency mechanisms through engineered HIV-infected clones, enabling evaluation of viral reactivation and antiretroviral drug efficacy. The cell line is employed in preclinical screening of kinase inhibitors targeting JAK/STAT signaling abnormalities caused by TEL-JAK2 fusions. In immunotherapy development, Jurkat E6-1 derivatives modified with chimeric antigen receptors (CARs) test cytotoxic T-cell activation protocols. Xenograft models using this line assess leukemia progression in immunodeficient mice.

Inquiring Jurkat, Clone E6-1

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

AcceGen Scroll Top Button