For research use only
| Cat No. | ABC-TC0482 |
| Product Type | Human Lymphocytes Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Product Code | JurkatE6-1; Jurkat E6-1; Jurkat, Clone E6-1; Jurkat Clone E6-1; Jurkat (clone E6-1); JURKAT E-6.1; JURKAT E-61; Jurkat-CloneE61; Jurkat-E6; Jurkat E6; J.E6-1; E6-1 |
Jurkat, Clone E6-1 is a T cell leukemia model for apoptosis, T cell signaling, and cancer immunology studies, derived from a 14-year-old patient.
Jurkat, Clone E6-1 is a human acute T-cell leukemia cell line originally established from the peripheral blood of a 14-year-old male patient with T-cell acute lymphoblastic leukemia (T-ALL). This suspension-growing lymphoblast-like cell line exhibits rapid proliferation. Cytogenetic analysis of the Jurkat clone E6-1 reveals a pseudodiploid karyotype (modal chromosome number 46) with recurrent abnormalities, including deletions at 2p21-p23 and 18p11. 2, alongside pathogenic mutations such as a TEL-JAK2 (ETV6-JAK2) fusion gene and a frameshift mutation in SYK kinase that results in loss of protein expression. The cells uniformly express CD3 and CD4 surface markers, retaining functional T-cell receptor (TCR) signaling pathways. Their robust responsiveness to TCR stimulation (via PMA/ionomycin or anti-CD3/CD28) and consistent interleukin-2 (IL-2) production have established this clone as the gold standard for T-cell immunology research. While primarily utilized for in vitro research, this cell line has been employed in subcutaneous xenograft models of leukemia.
| Product Code | JurkatE6-1; Jurkat E6-1; Jurkat, Clone E6-1; Jurkat Clone E6-1; Jurkat (clone E6-1); JURKAT E-6.1; JURKAT E-61; Jurkat-CloneE61; Jurkat-E6; Jurkat E6; J.E6-1; E6-1 |
| Species | Human |
| Cat.No | ABC-TC0482 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lymphocytes Cell Lines |
Jurkat E6-1 cells serve as indispensable tools across multiple research domains. In immunology, they are extensively used to map T-cell activation pathways, including NF-κB, MAPK, and calcium flux signaling cascades. The cell line has become fundamental to immuno-oncology research, particularly for developing CAR-T therapies and screening checkpoint inhibitor mechanisms. Virologists employ Jurkat E6-1 to study HIV pathogenesis, leveraging its susceptibility to viral entry and replication. The clone’s compatibility with CRISPR-based gene editing enables precise investigation of gene function through knockout or activation studies. Additionally, these cells are pre-adapted for high-throughput screening and xenograft modeling in NSG mice, providing versatile platforms for both in vitro and in vivo applications.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
