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Transfected Stable Cell Lines

KLN205/STAT3 Reporter (Luc) Stable Cell Line

  • For research use only

Cat No.

ABC-RC009Y
Product Type

Reporter Stable Cell Lines
Cell Type

Epithelial
Species

Mouse
Host Cell

KLN205
Source Organ

Lung
Disease

Squamous Cell Carcinoma
Storage

Liquid Nitrogen

KLN205/STAT3 Reporter (Luc) Stable Cell Line by AcceGen provides quantitative bioluminescent monitoring of STAT3 pathway activation in cancer research.

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  • KLN205/STAT3 Reporter (Luc) Stable Cell Line
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Home | Transfected Stable Cell Lines | KLN205/STAT3 Reporter (Luc) Stable Cell Line

Description

KLN205/STAT3 Reporter (Luc) Stable Cell Line is a bioluminescent reporter model derived from murine lung squamous carcinoma KLN205 cells, featuring stable integration of a luciferase gene under STAT3-responsive promoter elements. This engineered system enables quantitative, real-time monitoring of STAT3 signaling activity through luciferase expression while maintaining the epithelial morphology and malignant characteristics of parental KLN205 cells. The reporter provides a powerful platform for investigating IL-6/JAK/STAT3 signaling in response to cytokines such as IL-6, EGF, and OSM or pharmacological inhibitors. Applications include high-throughput drug screening, evaluation of STAT3 in epithelial-mesenchymal transition (EMT), tumor–microenvironment crosstalk, and preclinical testing of JAK/STAT3 inhibitors. All cells are rigorously tested and confirmed negative for mycoplasma, fungi, yeast, and bacteria.

Species

Mouse
Cat.No

ABC-RC009Y
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Squamous Cell Carcinoma
Biosafety Level

2
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Lines
Host Cell

KLN205
Gene Info

Luciferase (STAT3-responsive reporter)
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The KLN205/STAT3 Reporter (Luc) Stable Cell Line enables real-time bioluminescent monitoring of STAT3 pathway activity in lung carcinoma research. It provides a sensitive tool for studying IL-6/JAK/STAT3 signaling, cancer immune evasion, EMT, and drug resistance. This cell line is particularly suited for high-throughput screening of STAT3-targeting therapeutics and mechanistic studies of tumor–microenvironment interactions.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
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