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Tumor Cell Lines

KP-4

  • For research use only

Cat No.

ABC-TC0544

Product Type

Human Pancreas Cancer Cell Lines

Cell Type

Epithelial-like

Species

Human

Growth Conditions

37 ℃, 5% CO2

Source Organ

Pancreas

Product Code

KP 4; KP4

KP-4 Pancreatic Cancer Cells secrete PTHrP and are suitable for studying ductal adenocarcinoma, tumor signaling, and targeted drug inhibition.

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Description

KP-4 is a human pancreatic ductal cell carcinoma (PDAC) cell line derived from a 50-year-old Japanese male patient with metastatic PDAC in ascitic fluid. The cells exhibit epithelial-like morphology and show low expression of E-cadherin and high expression of vimentin mRNA. KP-4 cells secrete parathyroid hormone-related peptide (PTHrP), which makes them a valuable model for studying PTHrP regulation and its role in cancer. These cells are highly metastatic and can metastasize to the liver and lungs. KP-4 cells have a modal chromosome number of approximately 52–54 and carry a KRAS mutation (p.Gly12Asp). The cells have a doubling time of around 27 hours.
Product Code

KP 4; KP4

Species

Human

Cat.No

ABC-TC0544

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial-like

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Pancreas

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Pancreas Cancer Cell Lines

Application

  • KP-4 can be used to investigate how cancer cells evade apoptosis.. It was found that PI3K inhibitor can inactivate Akt, resulting in inhibition of cell proliferation in human pancreatic ductal carcinoma cell lines, PSN-1[a], PANC-1[b], and KP-4, and cell cycle arrested in the G1 phase with the PI3K inhibitor. Further studies using KP-4 may clarify whether the PI3K-AKT pathway supports proliferation in pancreatic ductal carcinoma. Otherwise, KP-4 can be applied in the field of identifying mutants and essential gene profiles of human pancreatic carcinoma for screening target genes and developing RNA drugs.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Inquiring KP-4

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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