For research use only
| Cat No. | ABC-TC0544 |
| Product Type | Human Pancreas Cancer Cell Lines |
| Cell Type | Epithelial-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Product Code | KP 4; KP4 |
KP-4 Pancreatic Cancer Cells secrete PTHrP and are suitable for studying ductal adenocarcinoma, tumor signaling, and targeted drug inhibition.
KP-4 (KP4) is a human pancreatic ductal cell carcinoma (PDAC) cell line derived from a 50-year-old Japanese male patient with metastatic PDAC in ascitic fluid. The cells exhibit epithelial morphology with characteristic cobblestone-like growth patterns. They show low expression of E-cadherin and high expression of vimentin, a critical feature in PDAC progression. These pancreatic cancer cell lines have a modal chromosome number of approximately 52–54 and carry a KRAS mutation (p. Gly12Asp(G12D)). KP-4 cells secrete parathyroid hormone-related peptide (PTHrP), which makes them a valuable model for studying PTHrP regulation and its role in hypercalcemia and bone metastasis. When transplanted into immunodeficient (nude) mice, these cells exhibit high tumorigenicity and metastatic potential, with preferential dissemination to the liver and lungs. As a widely used pancreatic cancer cell lines, KP-4 is occasionally compared with models such as the KB cell line in studies involving tumor progression and therapeutic screening.
| Product Code | KP 4; KP4 |
| Species | Human |
| Cat.No | ABC-TC0544 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
The KP-4 cell line is widely used to study pancreatic cancer metastasis mechanisms, particularly liver tropism. Researchers utilize KP-4 to evaluate chemoresistance patterns and test novel targeted therapies against KRAS or TGF-β pathways. The line is valuable for developing orthotopic PDAC mouse models and studying tumor-stroma interactions through co-cultures with pancreatic stellate cells. Its metastatic origin makes it ideal for investigating circulating tumor cell biology and metastatic niche formation.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
