Monkey Intestinal Fibroblasts

Description

Monkey Intestinal Fibroblasts (MIFs) are mesenchymal cells derived from the connective tissue of the monkey intestine, primarily isolated from the lamina propria or submucosa. These cells exhibit a spindle-shaped or stellate morphology, typical of fibroblasts, with elongated cytoplasmic processes and a prominent, oval nucleus. These cells play a crucial role in intestinal homeostasis by regulating ECM remodeling, tissue repair, and immune modulation through cytokine secretion (e.g., TGF-β, IL-6). They interact with epithelial and immune cells to maintain mucosal integrity and respond to inflammatory stimuli. MIFs are characterized by the expression of the fibroblast-associated marker Vimentin. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.