1
Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
| Species | Human |
| Cat.No | ABC-TC0724 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
The NB-1 cell line is a human neuroblastoma cell line originally isolated from the cervical lymph node metastasis of a 2-year-old male patient with neuroblastoma. This cell line exhibits a neuronal-like morphology. NB-1 grows semi-adherently and achieving a doubling time of 40–60 hours. Karyotypic analysis reveals ALK gene amplification (2p23 locus) and a novel truncated ALK variant (ALKdel2-3) lacking exons 2–3, and harbors chromosomal instability, including 1p deletion and 17q gain. NB-1 also overexpresses GD2, a tumor-associated ganglioside. This cell line is tumorigenic, forming subcutaneous tumors in nude mice, and exhibits enhanced metastatic potential in experimental models.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
The NB-1 cell line offers valuable applications in various research areas. It is used to study the in vitro differentiation ability of neuroblastoma cells, investigating both morphological and functional changes during differentiation. Additionally, NB-1 cells are employed to explore the radiosensitivity of human neuroblastoma cells, helping to understand their response to radiation therapy. Furthermore, researchers utilize this cell line to investigate genetic abnormalities linked to the pathogenesis of neuroblastomas. Finally, NB-1 cells are instrumental in predictive modeling of anticancer drug sensitivity, aiding in the development of personalized treatment strategies for neuroblastoma patients.
