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SH-Sy5y; SHSY5Y; SHSY-5Y; SK-SH-SY5Y; SY5Y; SH-SY5Y Parental






1 vial

Biosafety Level


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Dry Ice


Liquid Nitrogen


Human neuroblastoma cell line SH-SY5Y is a subline of the SK-N-SH cells, which was established in culture in 1970 from a bone marrow biopsy of a metastatic neuroblastoma of a 4-year-old female and has undergone three rounds of clonal selection.
This is a relatively homogeneous neuroblast-like cell line. The initial characterization of the SH-SY5Y cell line showed moderate activity of dopamine-β-hydroxylase and negligible levels of choline acetyl-transferase, acetylcholinesterase and butyryl-cholinesterase, basal noradrenaline (NA) release and tyrosine hydroxylase activity. In addition, SH-SY5Y neuroblastoma cells also express opioids, muscarinic and nerve growth factor receptors.

Why choose SH-SY5Y from AcceGen?
All SH-SY5Y cells are stored frozen in the cell culture kit. Each vial contains > 5×10^5 cells or can be customized according to requirements. All cells are tested negative for mycoplasma, bacteria, yeast, and fungi.
We provide customers with the best training program optimized by our technicians. If you have any questions, technical service representatives are available to answer your product questions timely.
Our cell products are of high purity, easy to obtain, and could be used in scientific research and laboratories.



Source Organ


Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).


For research use only
Based on its human origin, catecholaminergic neuron characteristics, and easy maintenance, SH-SY5Y neuronal cells are widely used in laboratory medical scientific research:
-Establish neurological disorders models, such as Parkinson’s Disease (PD)
-Drug screening
-Neuroprotection and neurotoxicity assay
-Co-culture with other neuron cells
-Study neural development and signaling
-Research on the Mechanism of Nervous System Diseases

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type


Growth Mode

Adherent and Suspension

Product Type

Human Bone Marrow Neuroblast Cell Lines

Product Image

AcceGen Frozen Cells & Cell Lines

AcceGen product mpp-89 cell line

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