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| Product Code | H292; H-292; NCI-HUT-292; Hut292; NCIH292 |
| Species | Human |
| Cat.No | ABC-TC488S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
The NCI-H292 cell line is a human epithelial tumor cell line derived from a 32-year-old African American female with lung mucoepidermoid carcinoma. The cells exhibit polygonal morphology with mucin-containing granules and form adherent monolayers in culture. Genetically, they are near-diploid with a modal chromosome number of 47 and exhibit microsatellite instability (MSI-low). Key mutations include a CRTC1-MAML2 fusion and an NF2 frameshift mutation. The cells overexpress MUC5AC, making them ideal for studying mucin regulation in airway epithelium. Tumorigenic and metastatic in nude mice, NCI – H292 is valuable for lung cancer and respiratory viral infection research, particularly for studying the interaction between respiratory viruses and host cells.
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The NCI – H292 cell line offers diverse and valuable applications in biomedical research. Firstly, it can be utilized to evaluate the replication efficiency of certain respiratory viruses within the cell line. Additionally, NCI – H292 cells serve as a substitute cell model for the isolation and propagation of human paramyxoviruses. Moreover, these cells are extensively employed as a model in transfection studies to investigate the role of respiratory viruses and their gene expression in the pathogenesis of respiratory diseases.
