For research use only
| Cat No. | ABC-TC0907 |
| Product Type | Human Lung Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | PC9; PC-9/S1; PC-9S1 |
PC-9 cells carry EGFR exon 19 deletion and are used in NSCLC modeling, drug sensitivity testing, and targeted therapy evaluation in lung cancer studies.
The PC-9 cell line is a human non-small cell lung cancer (NSCLC) cell line derived from a patient with pulmonary adenocarcinoma. These epithelial cells exhibit a heterogeneous morphology with a mix of round and spindle-shaped cells. They are known for their ability to grow both adherently and in suspension. PC-9 cells harbor an EGFR exon 19 deletion mutation (ΔE746-A750), which makes them highly sensitive to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. The line exhibits near-diploid karyotype with chromosomal abnormalities characteristic of transformed cells. They express lung epithelial markers, including cytokeratins and surfactant proteins, and have an active EGFR/PI3K/AKT signaling axis. PC-9 cells are tumorigenic in nude mice and are widely used in lung cancer drug resistance studies and targeted therapy research.
| Product Code | PC9; PC-9/S1; PC-9S1 |
| Species | Human |
| Cat.No | ABC-TC0907 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
PC-9 cells are widely used in cancer research. They can be used to investigate the impact of α-tocopherol on cytotoxic drugs, investigating whether it enhances or diminishes their effectiveness against NSCLC. Additionally, PC-9 cells serve as a model to study resistance to tyrosine kinase inhibitors (TKIs) in lung cancer, helping understand the mechanisms involved. Moreover, they can be utilized in tumorigenicity studies to assess the tumorigenic potential and characteristics of NSCLC. These applications contribute to advancing our understanding of NSCLC biology, drug resistance, and the development of effective treatment strategies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
PC-9 is a human non-small cell lung cancer (NSCLC) cell line derived from lung adenocarcinoma. It is commonly used in cancer research to study EGFR mutations, tumor biology, and responses to targeted therapies.
PC-9 cells were originally derived from a patient’s lung adenocarcinoma tissue. Our cell line is the same as RIKEN’s PC-9 (RCB4455) line.
