For research use only
| Cat No. | ABC-TC0914 |
| Product Type | Human Liver Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Product Code | PLC PRF 5; PLC/PRF5; PLCPRF5; PLC-8024; PLC8024; PLC |
PLC-PRF-5 cells are HBV-positive hepatocellular carcinoma cells with c-myc overexpression and TP53 mutations, tumorigenic in murine xenograft models.
PLC-PRF-5 is a well-characterized human hepatocellular carcinoma cell line originally derived from a primary liver tumor of a 24-year-old male patient. This epithelial-like adherent cell line maintains key hepatocellular carcinoma features, including tumorigenicity in nude mice. Its most distinctive characteristic is the stable secretion of hepatitis B surface antigen (HBsAg) due to integrated HBV DNA fragments (genotype D, subtype ayw), although it cannot produce infectious viral particles. Molecular analyses reveal characteristic HCC alterations including c-myc and c-ha-ras overexpression, frequent TP53 mutations (particularly R249S), and chromosome 8q24 amplification. These attributes, combined with its preserved hepatoma phenotype, make PLC-PRF-5 particularly valuable for studying HBV-associated hepatocarcinogenesis, HCC biomarker discovery, and therapeutic response evaluation. The cell line has been extensively validated through multiple studies since its original establishment.
| Product Code | PLC PRF 5; PLC/PRF5; PLCPRF5; PLC-8024; PLC8024; PLC |
| Species | Human |
| Cat.No | ABC-TC0914 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Liver Cancer Cell Lines |
PLC-PRF-5 is a hepatocellular carcinoma (HCC) cell line widely used in liver cancer research, particularly for studying tumor progression mechanisms. Its HBsAg production makes it relevant for hepatitis B virus (HBV) infection studies, linking viral persistence to oncogenesis. While primarily an HCC model, it may also aid research on liver complications of systemic infections (e.g., STI-associated pathologies). Additionally, PLC-PRF-5 helps identify prognostic biomarkers for liver cancer, advancing therapeutic development.
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