Rat Aortic Endothelial Cells (RAECs) are primary cells isolated from the aortic tissue of rats. These cells exhibit adherent growth and display typical endothelial cells morphology. Functionally, RAECs regulate vascular tone by secreting vasoactive factors such as nitric oxide (NO), and they actively modulate inflammatory responses. RAECs are implicated in atherosclerosis, diabetic vascular complications, and hypertension-related endothelial dysfunction, particularly under conditions of oxidative stress or chronic inflammation. These cells demonstrate high expression of endothelial-specific markers, including CD31 (PECAM-1) and von Willebrand factor (vWF). RAECs maintain functional characteristics in early passages. Their sensitivity to shear stress and cytokine-mediated activation makes them particularly suitable for modeling vascular pathophysiology in vitro.
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