Rat Astrocytes-cerebellar

Description

Rat Cerebellar Astrocytes are primary glial cells isolated from the cerebellum of rats. These polygonal to stellate cells express classic astrocytic markers GFAP, S100β, and ALDH1L1, and form extensive processes that mirror their in vivo morphology. They play crucial roles in supporting Purkinje neurons, regulating extracellular ion and neurotransmitter homeostasis, and contributing to synapse stabilization and cerebellar circuitry. Notably, cerebellar astrocytes display distinctive metabolic phenotypes compared to cortical astrocytes—exhibiting lower basal glycolysis and mitochondrial respiration, with a preferential fuel usage of glutamine and fatty acids. These cells are also key modulators of the cerebellar extracellular matrix and gliotransmission pathways, essential for motor coordination and signaling. Each lot undergoes rigorous screening and isolation procedures and is tested to ensure it is free from contamination by Mycoplasma, Fungi, Yeast, and Bacteria.